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czrA [2017-8-11 16:0:3]
transcriptional repressor (ArsR family), cadA and czcD
function
regulation of resistance against toxic metal cations
product
transcriptional repressor (ArsR family)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]Gene
Coordinates
2,084,786 → 2,085,109
The protein
Protein family
[SW|ArsR family]Effectors of protein activity
DNA-binding activity of CzrA is inactivated by high concentrations of toxic metal ions (induction)Structure
[PDB|1R1U] (the apo-repressor from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530][PDB|1R1V] (the Zn(II) form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530][PDB|2KJB] (the DNA-bound form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|19822742]Expression and Regulation
Operons
genes
[gene|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B412 (yozA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1411 NBRP B. subtilis, Japan]References
15948947,16430705,14568530,19822742,25213752,22007899 
